- 化学性质
溶于DMSO,水中溶解度：<0.1 g/100 mL ，21°C
密度：1.34
熔点：>170℃
可溶性两性霉素B简介 Amphotericin B solubilized ：
Application Polyene antifungal antibiotic from Streptomyces. Affinity for sterols,
primarily ergosterols, of fungal cell membranes. Forms channels in the membranes,
causing small molecules to leak out.
Antimicrobial spectrum: fungi and yeast.
Recommended for use in cell culture applications at 5.6 mg (solid)/L.
Biochem/physiol Actions Mode of Action: Interferes with fungal membrane permeability
by forming channels in the membranes and causing small molecules to leak out.
Antimicrobial spectrum: Yeasts and molds.
Packaging Package size based on amphotericin B
质量标准
项目 USP级
（USP Grade）
外观Appearance 黄色或桔黄色粉末
两性霉素A Amphotericin A ≤15%
紫外光谱UV-Spectrum: 符合
鉴别试验Identification 合格
干燥损失Loss on Drying ≤5 %
含量Assay 750 μg/mg
灼烧残渣Residue on Ignition ≤0.5 %
溶解性试验Solubility: 溶液橙色透明(10 %, DMF/1 M HCl 3 : 1)
用途
多烯类抗真菌药物。本品与真菌细胞膜上的甾醇结合，损伤膜的通透性，导致菌细胞内钾离子、核苷酸、氨基酸等外漏，破坏正常代谢而起抑菌作用。
