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- 化学性质
蓝紫色有光泽的结晶。360℃以上分解。溶于水、甲醇、丙醇、乙酸丁酯和环已酮,微溶于苯、四氯化碳和醚,几乎不溶于石油醚。其水溶液对酸、碱均不稳定。
熔点:360℃
质量标准
外观Appearance 蓝紫色粉末
紫外光谱鉴定UV spectrometry 符合
纯度Purity ≥99.0% (HPLC)
用途
Inhibitor for studies of cell-free protein biosynthesis. Mitomycin C inhibits DNA synthesis.
该品和博来霉素及其衍生物派来霉素都是破坏DNA的抗生素类抗癌药,可使细胞DNA解聚,抑制增生细胞的DNA的复制。小鼠静脉注射LD50为5ml/kg。
该品抗瘤谱较广,用于胃癌、乳腺癌效果好。对肺癌、肝癌、恶性化淋巴瘤、何杰金氏病、网状细胞肉瘤、子宫癌、白血病、肠道癌和胰腺癌等均有一定疗效,但缓解期较短。与尿激酶合用可提高疗效,该品作用迅速,但治疗接线员数不高,毒性大。
危险性质
储存方式
密闭保存。储存温度 2-8°C
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